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The first avian influenza A (H7N9) viral infection in humans in Zhejiang Province, China: a death report

Enfu Chen, Fenjuan Wang, Huakun Lv, Yanjun Zhang, Hua Ding, Shelan Liu, Jian Cai, Li Xie, Xiaoping Xu, Chengliang Chai, Haiyan Mao, Jimin Sun, Junfen Lin, Zhao Yu, Lianhong Li, Zhiping Chen, Shichang Xia

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 333-344 doi: 10.1007/s11684-013-0275-1

Abstract:

This study reports the first death caused by a novel avian influenza A (H7N9) virus in Zhejiang ProvinceThis H7N9 virus from Zhejiang is highly similar to isolates obtained from Shanghai, Jiangsu, Anhui, etcfor H7N9 RNA.influenza A (H7N9).Person-to-person transmission of the H7N9 virus was not detected among close contacts, but such transmission

Keywords： avian influenza A (H7N9) virus     epidemiology     contacts     person-to-person transmission    

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Research progress on human infection with avian influenza H7N9

Xiaoxin Wu, Lanlan Xiao, Lanjuan Li

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 8-20 doi: 10.1007/s11684-020-0739-z

Abstract: Since the first case of novel H7N9 infection was reported, China has experienced five epidemics of H7N9During the fifth wave, a highly pathogenic H7N9 strain emerged.Meanwhile, the H7N9 virus continues to accumulate mutations, and its affinity for the human respiratorycharacteristics of H7N9, the key gene mutations of the virus, and H7N9 vaccine, thus providing a scientificbasis for further monitoring and prevention of H7N9 influenza epidemics.

Keywords： H7N9     pandemic     epidemiology     mutations     vaccine     influenza    

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Compiling of comprehensive data of human infections with novel influenza A (H7N9) virus

Ying Wu, George F. Gao

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 275-276 doi: 10.1007/s11684-013-0285-z

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Universal influenza virus vaccines: what can we learn from the human immune response following exposureto H7 subtype viruses?

Daniel Stadlbauer, Raffael Nachbagauer, Philip Meade, Florian Krammer

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 471-479 doi: 10.1007/s11684-017-0602-z

Abstract:

Several universal influenza virus vaccine candidates based on eliciting antibodies against the hemagglutininHere we review what is known about the human humoral immune response to vaccination and infection with H7subtype influenza viruses on a polyclonal and monoclonal level.to the group 1 stalk domain, H7 exposure induces both group 2 and cross-group antibody responses.virus vaccine candidates.

Keywords： universal influenza virus vaccine     hemagglutinin stalk     H7N9    

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Endemicity of H9N2 and H5N1 avian influenza viruses in poultry in China poses a serious threat to poultry

Jiao HU,Xiufan LIU

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1,   Pages 11-24 doi: 10.15302/J-FASE-2016092

Abstract: The H9N2 and H5N1 avian influenza viruses (AIVs) have been circulating in poultry in China and becomeendemicity makes them actively involved in the emergence of the novel lineages of other subtypes of influenzaviruses, such as the well-known viruses of the highly pathogenic avian influenza (HPAI) H5N2 and the2013 novel H7N7, H7N9 and H10N8 subtypes, thereby threatening both the poultry industry and public health

Keywords： avian influenza virus     H9N2     H5N1     novel viruses     public health    

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Avian influenza A: an avian influenza virus from low pathogenic to highly pathogenic

William J. Liu, Haixia Xiao, Lianpan Dai, Di Liu, Jianjun Chen, Xiaopeng Qi, Yuhai Bi, Yi Shi, George F. Gao, Yingxia Liu

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 507-527 doi: 10.1007/s11684-020-0814-5

Abstract: The avian influenza A (H7N9) virus is a zoonotic virus that is closely associated with live poultry marketsFive waves of the H7N9 influenza epidemic occurred in China between March 2013 and September 2017.H7N9 with low-pathogenicity dominated in the first four waves, whereas highly pathogenic H7N9 influenzaHere, we review the characteristics of the H7N9 viruses that were identified while controlling the spreadThese data provide tools for minimizing the future threat of H7N9 and other emerging and re-emerging

Keywords： H7N9     HPAIV     epidemiology     clinical features     pathogenesis     hemagglutinin     immunity     vaccine    

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Study of Mesenchymal Stem Cell Treatment for Acute Respiratory Distress Syndrome Induced by Epidemic InfluenzaA (H7N9) Infection: A Hint for COVID-19 Treatment Article

Jiajia Chen, Chenxia Hu, Lijun Chen, Lingling Tang, Yixin Zhu, Xiaowei Xu, Lu Chen, Hainv Gao, Xiaoqing Lu, Liang Yu, Xiahong Dai, Charlie Xiang, Lanjuan Li

Engineering 2020, Volume 6, Issue 10,   Pages 1153-1161 doi: 10.1016/j.eng.2020.02.006

Abstract:

H7N9 viruses quickly spread between mammalian hosts and carry the risk of human-to-human transmissionrespiratory distress syndrome (ARDS), lung failure, and acute pneumonia are major lung diseases in H7N9, and was used to treat H7N9-induced ARDS in 2013.The transplant of MSCs into patients with H7N9-induced ARDS was conducted at a single center throughBecause H7N9 and the coronavirus disease 2019 (COVID-19) share similar complications (e.g., ARDS and

Keywords： H7N9     Mesenchymal stem cell     Epidemic Influenza A     Acute respiratory distress syndrome     COVID-19     Stem    

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Pathogenesis of pandemic H1N1 2009 influenza virus infection and the implication on management

Kelvin Kai-Wang TO FRCPath, Iris Wai-Sum LI FRCP, Ivan Fan-Ngai HUNG FRCP, Vincent Chi-Chung CHENG FRCPath, Kwok-Yung YUEN MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 147-156 doi: 10.1007/s11684-010-0030-9

Abstract: The pandemic H1N1 2009 influenza virus has caused the first influenza pandemic of the 21st century, leading

Keywords： influenza A virus     H1N1 subtype     pandemic     pathogenesis     virulence factors     immunity     management     antiviral    

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Assessment of vaccination strategies against highly pathogenic avian influenza in China

Honglei SUN,Jinhua LIU

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 4,   Pages 277-281 doi: 10.15302/J-FASE-2014036

Abstract: Vaccination for highly pathogenic avian influenza (HPAI) has been implemented in China for a decade,however, the virus is still present in poultry.A series of recombinant vaccines, Re-1 to Re-7, have been developed and used, and Re-8 will also be usedHere, we review the epidemiology of H5 HPAI along with the development, usage and problems of vaccines

Keywords： highly pathogenic avian influenza     vaccine     vaccination     control    

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Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 34-47 doi: 10.1007/s11684-017-0606-8

Abstract:

Influenza is a major global health problem, causing infections of the respiratory tract, often leadinglast seven decades, vaccination strategies have been utilized to protect people from complications of influenzastrain-specific antibody responses, they fail to generate cross-protection against seasonal, pandemic and avianMoreover, vaccines designed to generate influenza-specific T-cell responses are yet to be optimized.We summarize the current knowledge on influenza-specific innate MAIT and gd T cells as well as adaptive

Keywords： influenza     innate T cells     CD4+ and CD8+ T cells     vaccination    

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Recent advances in “universal” influenza virus antibodies: the rise of a hidden trimeric interface in

Yulu Wang, Dan Hu, Yanling Wu, Tianlei Ying

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 149-159 doi: 10.1007/s11684-020-0764-y

Abstract: Influenza causes seasonal outbreaks yearly and unpredictable pandemics with high morbidity and mortalityDespite significant efforts to address influenza, it remains a major threat to human public health.virus strains and the rapid emergence of drug-resistant variants.Moreover, designing a universal influenza vaccine that is sufficiently immunogenic to induce universalvirus to promote the development of universal anti-influenza antibodies or vaccines and extend the discovery

Keywords： influenza virus     neutralizing antibody     hemagglutinin     globular head region     trimeric interface    

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Seroprevalence of influenza viruses in Shandong, Northern China during the COVID-19 pandemic

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 984-990 doi: 10.1007/s11684-022-0930-5

Abstract: However, the influenza risk in China warrants cautious assessment.Hemagglutination inhibition was performed to test antibodies against four influenza vaccine strains.A combination of descriptive and meta-analyses was adopted to compare the seroprevalence of influenzaThe overall seroprevalence values against A/H1N1pdm09, A/H3N2, B/Victoria, and B/Yamagata were 17.8H1N1pdm09 and A/H3N2 were significantly low

Keywords： influenza virus     seroprevalence     antibody     COVID-19     cross-sectional study    

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Salmonella-Delivered COBRA-HA1 Antigen Derived from H1N1 Hemagglutinin Sequences Elicits Broad-SpectrumProtection Against Influenza A Subtypes Article

Ram Prasad Aganja, Amal Senevirathne, Chandran Sivasankar, John Hwa Lee

Engineering 2024, Volume 32, Issue 1,   Pages 42-57 doi: 10.1016/j.eng.2023.08.001

Abstract: high demand to address the uncertainties of antigenic drift and the reduced effectiveness of current influenzaCOBRA) was used to generate a consensus sequence of the hemagglutinin globular head portion (HA1) of influenzavirus samples collected from 1918 to 2021 to trace evolutionary changes and incorporate them into thedelivered into eukaryotic cells by Salmonella-mediated bactofection using a Semliki Forest virusThis approach can effectively combat seasonal H1N1 influenza strains and potential pandemic outbreaks

Keywords： COBRA     Influenza A     Salmonella     Vaccine     Broad spectral protection    

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Enhancement of open circuit voltage in organic solar cells by doping a fluorescent red dye

Qing LI, Junsheng YU, Yue ZANG, Nana WANG, Yadong JIANG

Frontiers in Energy 2012, Volume 6, Issue 2,   Pages 179-183 doi: 10.1007/s11708-012-0177-y

Abstract: In this paper, 4-(dicyanomethylene)-2-t-butyl-6-(1,1,7,7-tetramethyljulolidyl-9-enyl)-4H-pyran (DCJTB

Keywords： solar cells (OSCs)     open circuit voltage     fluorescent dye doping     4-(dicyanomethylene)-2-t-butyl-6-(1     1     7     7-tetramethyljulolidyl-9-enyl)-4H-pyran (DCJTB)    

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Post-surgical resection prognostic value of combined OPN, MMP7, and PSG9 plasma biomarkers in hepatocellular

Weiqi Rong, Yang Zhang, Lei Yang, Lin Feng, Baojun Wei, Fan Wu, Liming Wang, Yanning Gao, Shujun Cheng, Jianxiong Wu, Ting Xiao

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 250-258 doi: 10.1007/s11684-018-0632-1

Abstract: (MMP7), and pregnancy specific glycoprotein 9 (PSG9) in patients with HCC.Plasma OPN, MMP7, and PSG9 levels were determined by enzyme-linked immunosorbent assay.High OPN (≥149.97 ng/mL), MMP7 (≥2.28 ng/mL), and PSG9 (≥45.59 ng/mL) were prognostic indicators of reducedPlasma OPN+MMP7+PSG9 elevation in combination was a prognostic factor for OS ( <0.001).These findings suggested that OPN, MMP7, PSG9 and their combined panels may be useful for aiding in tumor

Keywords： biomarkers     OPN     MMP7     PSG9     HCC     prognosis    

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Title Author Date Type Operation

The first avian influenza A (H7N9) viral infection in humans in Zhejiang Province, China: a death report

Enfu Chen, Fenjuan Wang, Huakun Lv, Yanjun Zhang, Hua Ding, Shelan Liu, Jian Cai, Li Xie, Xiaoping Xu, Chengliang Chai, Haiyan Mao, Jimin Sun, Junfen Lin, Zhao Yu, Lianhong Li, Zhiping Chen, Shichang Xia

Journal Article

Research progress on human infection with avian influenza H7N9

Xiaoxin Wu, Lanlan Xiao, Lanjuan Li

Journal Article

Compiling of comprehensive data of human infections with novel influenza A (H7N9) virus

Ying Wu, George F. Gao

Journal Article

Universal influenza virus vaccines: what can we learn from the human immune response following exposureto H7 subtype viruses?

Daniel Stadlbauer, Raffael Nachbagauer, Philip Meade, Florian Krammer

Journal Article

Endemicity of H9N2 and H5N1 avian influenza viruses in poultry in China poses a serious threat to poultry

Jiao HU,Xiufan LIU

Journal Article

Avian influenza A: an avian influenza virus from low pathogenic to highly pathogenic

William J. Liu, Haixia Xiao, Lianpan Dai, Di Liu, Jianjun Chen, Xiaopeng Qi, Yuhai Bi, Yi Shi, George F. Gao, Yingxia Liu

Journal Article

Study of Mesenchymal Stem Cell Treatment for Acute Respiratory Distress Syndrome Induced by Epidemic InfluenzaA (H7N9) Infection: A Hint for COVID-19 Treatment

Jiajia Chen, Chenxia Hu, Lijun Chen, Lingling Tang, Yixin Zhu, Xiaowei Xu, Lu Chen, Hainv Gao, Xiaoqing Lu, Liang Yu, Xiahong Dai, Charlie Xiang, Lanjuan Li

Journal Article

Pathogenesis of pandemic H1N1 2009 influenza virus infection and the implication on management

Kelvin Kai-Wang TO FRCPath, Iris Wai-Sum LI FRCP, Ivan Fan-Ngai HUNG FRCP, Vincent Chi-Chung CHENG FRCPath, Kwok-Yung YUEN MD,

Journal Article

Assessment of vaccination strategies against highly pathogenic avian influenza in China

Honglei SUN,Jinhua LIU

Journal Article

Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Journal Article

Recent advances in “universal” influenza virus antibodies: the rise of a hidden trimeric interface in

Yulu Wang, Dan Hu, Yanling Wu, Tianlei Ying

Journal Article

Seroprevalence of influenza viruses in Shandong, Northern China during the COVID-19 pandemic

Journal Article

Salmonella-Delivered COBRA-HA1 Antigen Derived from H1N1 Hemagglutinin Sequences Elicits Broad-SpectrumProtection Against Influenza A Subtypes

Ram Prasad Aganja, Amal Senevirathne, Chandran Sivasankar, John Hwa Lee

Journal Article

Enhancement of open circuit voltage in organic solar cells by doping a fluorescent red dye

Qing LI, Junsheng YU, Yue ZANG, Nana WANG, Yadong JIANG

Journal Article

Post-surgical resection prognostic value of combined OPN, MMP7, and PSG9 plasma biomarkers in hepatocellular

Weiqi Rong, Yang Zhang, Lei Yang, Lin Feng, Baojun Wei, Fan Wu, Liming Wang, Yanning Gao, Shujun Cheng, Jianxiong Wu, Ting Xiao

Journal Article